Villanova went down, costing President Obama one of his Final Four picks. His other Final Four picks - Kentucky, Kansas and Kansas State - play later Saturday.
The Big East has not been helpful to many brackets so far.
UPDATE: Two of Obama's Final Four picks made the Elite Eight. Kansas State goes down, and Kentucky trails by 14 with 4:12 to go.
UPDATE 2: All of President Obama's Final Four picks have been eliminated.