Thursday, all 16 AFC teams get to stay home for the holiday.
Six NFC teams will be competing for Thanksgiving themed postgame trophies.
Fox starts the day at 12:30 p.m. with the Eagles facing the Lions. The Cowboys host the Panthers on CBS at 4:30 p.m., and the night closes on NBC when the Bears invade Lambeau Field to face the Packers.
Sunday, the Redskins meet the Giants on Fox at 1 p.m. CBS offers Dolphins-Jets early before the Steelers take on the Steelers in the late afternoon slot.
NBC has the battle between the Broncos and Patriots Sunday night. The Ravens face the Browns on ESPN Monday night.
There's a pair of college football games Thanksgiving night, with South Florida-Central Florida on ESPN at 7:30 p.m. while FoxSports1 offers Texas Tech-Texas at 7:30 p.m.
Undefeated Iowa closes its regular season against Nebraska Friday at 3:30 p.m., following Navy-Houston at noon.
Missouri and Arkansas battle on CBS at 2:30 p.m., while Fox brings the Apple Cup between Washington and Washington State at 3:30 p.m.
Miami meets Pittsburgh at noon on ESPN2 and it's Baylor taking on TCU on ESPN at 7:30 p.m.
Marshall heads to Western Kentucky on FoxSports1 at noon.
Notre Dame, hoping to make the four-team playoff, battle Stanford on Fox Saturday at 7:30 p.m.
Michigan and Ohio State have their annual matchup at noon on ABC. Rivalries take the air at 3:30 p.m., with North Carolina against North Carolina State or Southern Cal-USC. The game not on the air in your area will be on ESPN2.
In primetime, it's Bedlam between Oklahoma and Oklahoma State.
The Iron Bowl takes center stage on CBS at 3:30 p.m., with Alabama meeting Auburn.
ESPN starts its day at noon with Clemson-South Carolina. Michigan State tries to clinch the Big Ten East against Penn State at 3:30 p.m. before Florida State faces Florida at 7 p.m.
Georgia tangles with Georgia Tech on ESPN2 at noon. It's the Egg Bowl between Mississippi and Mississippi State at 7:15 p.m. and Nevada meets San Diego State at 10:45 p.m.
The ACC Network offers Duke-Wake Forest at 12:30 p.m.
West Virginia hosts Iowa State at noon on FoxSports1, followed by Kansas-Kansas State at 4 p.m. and Arizona State taking on California at 10 p.m.
Boston College battles Syracuse on Comcast at 12:30 p.m.
NBC Sports network has the Bayou Classic between Grambling and Southern at 5 p.m.
Conference USA takes the stage on MASN and MASN2 Saturday, with Old Dominion hosting Florida Atlantic on MASN at noon followed by Charlotte-Rice. MASN2 has Southern Mississippi taking on Louisiana Tech at noon before UTEP-North Texas.
It's Grey Cup day in Canada, with Ottawa battling Edmonton for the CFL title Sunday at 6:30 p.m. on ESPN2.
The Wizards tangle with the Celtics on Comcast Friday at 8 p.m. and the Raptors at home Saturday at 7 p.m.
The ESPN family of networks have a bunch of tournaments for its Feast Week. The Battle4Atlantis in the Bahamas has semifinals Thursday at 1 and 3:30 p.m., and two more games Friday at 12:30 p.m. and 3 p.m.
Top-ranked Kentucky meets South Florida Friday at 5 p.m.
ESPN2 has six contests Thursday, starting at noon with Alabama-Xavier. It's Wichita State-USC at 2 p.m., then Stanford plays Michigan State at 4:30 p.m. Michigan State meets Boston College at 6:30 p.m., followed by Iowa against Dayton and Santa Clara-Arizona in the nightcap at 11:30 p.m.
The NIT preseason tournament crowns its champion Friday at 3 p.m. There's semifinals of the Wooden Legacy at 5:30 p.m. and 11:30 p.m., sandwiched between Ohio State-Memphis and a semifinal at the AdvoCare Invitational at 9:30 p.m.
Sunday brings two more games from the AdvoCare Invitational at 12:30 p.m. and 4:30 p.m., along with Wisconsin-Oklahoma at 2:30 p.m.
FoxSports1 brings West Virginia's contest with Richmond at 5 p.m., then it's California-San Diego State from Las Vegas Thursday at midnight.
Friday, it's two contests from Las Vegas at 8 p.m. and 10:30 p.m. and Georgia faces Seton Hall Saturday at 7:30 p.m. Marquette faces Jackson State Sunday at 1:30 p.m.
MASN offers play from the Barclay Center Classic Friday, with Cincinnati-Nebraska at 6:30 p.m. followed by Tennessee taking on George Washington. Louisville plays St. Louis Saturday at 8 p.m.
Baylor faces Arkansas State at 1 p.m. on MASN2, and it's Oklahoma State-Long Beach State at 8:30 p.m.
Liberty meets Appalachian State Thursday at 3 p.m. on Comcast, and it's Old Dominion-VCU Saturday at 4 p.m.
Texas and Tennessee tangle on the women's hardcourt Sunday at 2:30 p.m. on ESPN.
NBC has Black Friday afternoon ice hockey, while the Blackhawks visit the Ducks on NBC Sports network at 5 p.m.
The Capitals host Tampa Bay Friday at 5 p.m. on Comcast.
Conference finals have their second leg in the MLS Sunday, with Dallas-Portland at 5 p.m. on ESPN and the Red Bulls clashing with Columbus on FoxSports at 7:30 p.m.
It's Manchester City-Southampton on NBC Sports network Saturday at 10 a.m., followed by Leicester City against Manchester United on NBC in 12:30 p.m.
Liverpool meets Swansea City Sunday at 11 a.m. on NBC Sports network.