No one has been able to stop Peyton Manning this season.
Will his former mates?
Manning and the Denver Broncos visit Indianapolis on NBC's Sunday night game at 8:25 p.m. Manning won one Super Bowl during his 14-year tenure with the Colts. His quest for a second title has gotten off to a good start, with 22 touchdown passes in six wins.
Andrew Luck took the Colts to the playoff after taking over Manning's quarterback slot, but his team enters the contest off a Monday night loss to San Diego.
In the afternoon, the Redskins host the Bears on Fox at 1 p.m. CBS has the doubleheader, with Patriots-Jets at 1 p.m. before the Ravens head to Pittsburgh at 4:25 p.m.
The winless Giants host Minnesota Monday at 8:30 p.m. on ESPN.
The National League series returns to St. Louis Friday for Game 6 at 8 p.m. on TBS. If the Dodgers win, Game 7 will be Saturday. It's back to Boston for the American League series Saturday at 4:30 p.m. Game 7, if necessary, will be Sunday at 8 p.m.
The college football weekend continues Friday at 8 p.m. when Louisville hosts Central Florida.
CBS offers an SEC doubleheader Saturday, as Georgia meets Vanderbilt at noon before Auburn takes on Texas A&M at 3:30 p.m.
The ACC has a pair of teams in the top five - Clemson and Florida State - and they meet on ABC at 8 p.m. In the afternoon, it's either Ohio State-Iowa or UCLA playing Stanford, with ESPN2 showing the game not seen over-the-air in your area.
Notre Dame meets Southern Cal on NBC at 7:30 p.m. and Fox goes early with TCU-Oklahoma State at noon.
ESPN starts and ends the day in the SEC. South Carolina meets Tennessee at noon, and Alabama battles Arkansas at 7 p.m. In between, Oklahoma plays Kansas at 3:30 p.m.
Minnesota takes on Northwestern at noon on ESPN2. The primetime doubleheader starts at 7 p.m. with LSU-Mississippi, then Oregon State goes to California at 10:30 p.m.
West Virginia welcomes Texas Tech at noon on FoxSports1, and Oregon hosts Washington State at 10 p.m.
Virginia hosts Duke at 3:30 p.m. on Comcast, after the CAA contest between Villanova and New Hampshire at noon.
MASN brings SMU at Memphis at noon, while MASN2 features Southern Mississippi taking on East Carolina.
ESPN has the BCS countdown show Sunday at 8:30 p.m.
There's high school football from New Jersey Friday at 8 p.m. on ESPN2, with Don Bosco Prep meeting Paramus Catholic. FoxSports1 heads to Florida for Cypress Bay at St. Thomas Aquinas at 7 p.m.
With five races left in the Chase for the Sprint Cup, NASCAR visits Talladega Sunday at 1 p.m. on ESPN. FoxSports1 has the truck race Saturday at 4 p.m.
Indy Car concludes its season in California Saturday at 8 p.m. on NBC Sports network.
The Capitals face Columbus Saturday at 7 p.m. on Comcast.
D.C. United travels to Kansas City Friday at 8 p.m. on NBC Sports network.
Dallas hosts Seattle on NBC Saturday at 2:30 p.m. while the Galaxy head to San Jose on ESPN Sunday at 9 p.m.
In the Premier League, NBC shows West Ham against Manchester United Saturday at 12:30 p.m. Newcastle United faces Liverpool at 7:45 a.m. on NBC Sports network, followed by Manchester United-Southampton. Sunday at 11 a.m., it's Aston Villa-Tottenham Hotspur.
On the college pitch, Syracuse plays North Carolina on Comcast Friday at 6:30 p.m. There's women's action Sunday on Comcast, as Syracuse meets N.C. State at 1 p.m. and Wake Forest goes against Clemson.
From Keeneland, MASN offers the Raven Run at 4:30 p.m. Saturday.
Iowa State takes on Texas in women's volleyball Saturday at 7 p.m. on MASN2. Comcast brings Duke against Georgia Tech Friday at 8:30 p.m.