It's one race down and two to go for Nyquist.
The Kentucky Derby winner will take on 10 other colts in the Preakness Stakes Saturday. NBC has coverage starting at 5 p.m. after NBC Sports network has earlier races starting at 2:30 p.m.
Derby runner-up Exaggerator will be among the horses hoping for a victory that ends hopes for a triple crown this year.
NBC Sports network has the Black-Eyed Susan Stakes Friday at 3 p.m.
The Cavaliers face the Raptors in Game 3 of their series Saturday at 8:30 p.m.
Oklahoma City hosts Golden State on TNT Sunday at 8 p.m.
San Jose takes St. Louis in the fourth game of the NHL Western Conference final Saturday at 7:15 p.m. on NBC Sports network. Tampa Bay tangles with Pittsburgh Friday at 8 p.m. on NBC Sports network, with Game 5 on NBC Sunday at 8 p.m.
The Orioles visit the Angels with games on MASN2 Friday and Saturday between a Saturday night contest on MASN.
The Nationals head to Miami for games on MASN Friday and Sunday.
Fox starts its summer run of Saturday baseball, featuring the Nationals and Marlins at 7:15 p.m. Other areas of the country get Cubs-Giants or Astros against the Rangers.
The Cardinals host the Diamondbacks Saturday at 4 p.m. on FoxSports1, and ESPN brings Cubs-Giants Sunday at 8 p.m.
On the college diamond, Creighton clashes with St. John's Saturday at noon on FoxSports1.
It's qualifying weekend at Indianapolis, with the drivers going for the poll Saturday at 4 p.m. on ABC. The final chances to make the 33-car field are Sunday at 4 p.m.
NASCAR gears up for its Memorial Day weekend festivities with the All-Star race Saturday at 9 p.m. on FoxSports1. The Truck Series goes Friday at 8:30 p.m.
North Carolina battles Notre Dame in the NCAA lacrosse quarterfinals Sunday at noon on ESPN2.
The road to the NCAA softball World Series continues on ESPN with two games on Friday - a possible final game of the Missouri regional at 7 p.m. before Wichita State faces Oklahoma at 9 p.m.
Texas takes on Texas A&M on ESPN2 at 4:30 p.m., followed by Marist-Tennessee at 7 p.m. It's off to the Oregon regional at 9 p.m. for Long Beach State's contest with Baylor before Oregon battles Fordham at 11:30 p.m.
ESPN has three games from a regional Saturday starting at noon, with ESPN2 going with five contests beginning at noon. There's a possible regional final Sunday at noon on ESPN and another at 7 p.m. on ESPN2.
The PGA tour visits Texas this weekend, with play on CBS Saturday and Sunday at 3 p.m.
Vancouver hosts Portland in MLS action Sunday at 4:30 p.m., then FoxSports1 offers San Jose against the Galaxy.
The United States has a friendly against Puerto Rico on FoxSports1 Sunday at 1 p.m.
In the Copa del Rey, Barcelona meets Sevilla Sunday at 3:25 p.m. on ESPN2.
The Tour of California cycling race continues on NBC Sports network Friday and Saturday at 5 p.m.
There's Olympic qualifying in Water Polo on NBC Sports network Sunday at 4 p.m.
NBC Sports network has motorcycle racing from the Hangtown Classic Saturday at 7 p.m.