It's Bay vs. Bay weekend in major league baseball.
The Nationals are home to San Francisco, while the Orioles continue a west coast swing in Oakland. The Nationals will be on MASN, with Orioles' contests with the A's on MASN2.
The Yankees host the Red Sox Saturday at 4 p.m. on FoxSports1 and Sunday night on ESPN. TBS offers Indians-Rays Sunday afternoon.
NFL network has several live games opening weekend of NFL exhibition games, including the Cowboys facing the Rams Saturday at 9 p.m. and the Los Angeles Chargers' first home preseason contest Sunday at 8 p.m. against the Seahawks.
North of the border, British Columbia clashes with Saskatchewan Sunday at 8 p.m. on ESPN2.
Little League baseball's road to Williamsport continues with six games on ESPN Friday, with six more Saturday at 11 a.m.
NASCAR's Monster Series visits Michigan Sunday at 3 p.m. on NBC Sports network. The Xfinity Series rolls through Mid-Ohio Saturday at 3:30 p.m. on NBC Sports network, while the Truck Series goes Saturday at 1 p.m. on FoxSports1.
It's time for the final golf major championship of the year, with CBS covering the PGA championship Saturday and Sunday at 2 p.m.
FoxSports1 has the United States' women's amateur championship Sunday at 4 p.m. The semifinals are Saturday at 4 p.m., after quarterfinals Friday at 6 p.m.
The new Premier League season gets going Friday at 3 p.m. with Arsenal taking on Leicester City on NBC Sports network. Watford faces Liverpool Saturday at 7:25 a.m. followed by Chelsea-Burnley. NBC has Manchester City meets Brighton and Hove Albion at 12:30 p.m.
Newcastle United battles Tottenham Hotspur Sunday at 8:25 a.m. with Manchester United against West Ham United at 10:55 a.m.
Real Madrid battles Barcelona in the first leg of the Spanish Super Cup Sunday at 4 p.m. on ESPN.
The Galaxy host New York City Saturday at 11 p.m. on ESPN2.
Phoenix meets Dallas in WNBA action Thursday at 8 p.m. on ESPN2.
The road to the U.S. Open tennis tournament continues with the Rogers Cup Friday at 12:30 p.m. on ESPN2. There's more action Friday at 6:30 p.m., and Saturday at 1 and 6 p.m. The finals are Sunday at 1:30 and 4:30 p.m.