Twenty colts are scheduled to enter the gates at Churchill Downs Saturday.
One leaves with a chance to win the Triple Crown.
NBC has coverage of the Kentucky Derby starting at 2:30 p.m., with the big race scheduled for around 6:45 p.m.
NBC Sports network has coverage of the Kentucky Oaks starting Friday at noon, and early races on Derby Day Saturday at noon.
The Orioles meet the White Sox on MASN2 Friday and Saturday before moving to MASN Sunday afternoon.
The Nationals take on Philadelphia on MASN Friday and Saturday before MASN2 takes over for Sunday's contest.
The Yankees visit the Cubs Saturday night on Fox and Sunday night on ESPN. FoxSports1 has the Indians facing the Royals Saturday at 4 p.m.
On the college diamond, Pittsburgh plays Georgia Tech Sunday at 6 p.m. on Comcast. Texas tangles with TCU Saturday at 1 p.m. on ESPN and South Carolina faces LSU Sunday at 3 p.m.
The NBA's conference semifinals continue Friday with Game 3 of Cavaliers-Raptors on ESPN at 7 p.m., with Spurs against Rockets in the nightcap.
ABC has the Warriors taking on the Jazz Saturday at 8:30 p.m., then the Warriors tangle with the Jazz Sunday at 3:30 p.m. TNT has the Wizards against Celtics at 6:30 p.m. before the Spurs meet the Rockets at 9 p.m.
St. Louis hosts Nashville Friday at 8 p.m. on NBC Sports network.followed by Game 5 between Edmonton and Anaheim at 10:30 p.m.
It's Game 5 matching the Rangers and Senators Saturday at 3 p.m. on NBC Sports network, and the Capitals and Penguins tangle on NBC at 7:15 p.m.
NASCAR visits Talladega for the weekend, with the Monster Series Sunday at 2 p.m. on Fox and the Xfinity Series Saturday at 1 p.m. on Fox.
Manchester City meets Crystal Palace Saturday at 7:40 a.m. on NBC Sports network. Liverpool tangles with Southampton Sunday at 7:40 a.m., followed by Arsenal-Manchester United.
In the MLS, Seattle takes on Toronto on ESPN Saturday at 2:55 p.m. Minnesota meets Sporting KC Sunday at 1:30 p.m.
The PGA tour's Wells Fargo championship will be on CBS Saturday and Sunday at 3 p.m.
ESPN has the men's volleyball championship Saturday at 7 p.m.
The CAA crowns its men's lacrosse champion Saturday at 1 p.m. on Comcast.
Comcast has a semifinal from the Ivy League women's lacrosse tournament Friday at 7 p.m. and final Sunday at 11 a.m. The CAA women battle for their championship Sunday at 1 p.m.
Oklahoma State meets Oklahoma in college softball Saturday at 5 p.m. on ESPN, followed by Auburn-Alabama at 8 p.m. It's Arizona against UCLA on ESPN2 Saturday at 9 p.m. Sunday, Auburn plays Alabama at 1 p.m. on ESPN2 and it's Arizona against UCLA at 4 p.m.
NBC Sports network offers USA Swimming from Atlanta Saturday at 7 p.m. and Sunday at 5 p.m.